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Video Game For Cancer Research Bets Human ‘Herd Intelligence’ Is Better Than AI

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The puzzle game GENIGMA was developed by scientists and gaming experts in Spain to aid in cancer research. (National Center for Genomic Analysis in Spain)



By Martin M Barillas

A new cellphone game that generates scientific data to detect altered genomic sequences may aid cancer research.


The game, available on Android and iOS devices in English, Catalan, Italian and Spanish, was developed as a collaboration between gaming professionals and researchers at the Centre for Genomic Regulation (CRG) and Spain’s National Center for Genomic Analysis (CNAG-CRG).

“Cell lines are responsible for the discovery of vaccines, chemotherapies for cancer or IVF for infertility. This makes them a pillar of modern biology,” said researcher Marc Marti-Renom of the Catalan Institution for Research and Advanced Studies in Barcelona. “However, the lack of genome reference maps limits current scientific progress.”

GENIGMA is a game players can access on smartphones that was developed by scientists and gaming experts to assist in genetic mapping in the service of cancer research. (National Center for Genomic Analysis in Spain)

Dubbed GENIGMA, the game is intended to aid research that uses cancer cell lines to study cancer and potential cures. Using these cell lines is limited by the scarcity of high-resolution genome reference maps to interpret the results of the research. New maps can pinpoint potential mutations and genes of therapeutic interest.

Science “can often feel inaccessible for most people,” according to design coordinator Oriol Ripoll, but by playing GENIGMA, they can learn about science while contributing to cancer research.

“Anyone with a smartphone from anywhere in the world can download GENIGMA for free and make a direct contribution to research, lending their logic and dexterity to the service of science,” said Elisabetta Broglio of Spain’s National Center for Genomic Analysis.

She said GENIGMA will analyze the “solutions provided by the players as a collective and not as individuals and will take advantage of creative solutions impossible to find with deterministic algorithms.”

GENIGMA can be played on iOS and Android smartphones, allowing players to contribute to medical research while solving puzzles. (National Center for Genomic Analysis in Spain)

Launched on Jan. 27, the #GenigmaChallenge will introduce players to new genome fragments from the T-47D breast cancer cell line every Monday for the next three months. The first genome for players to arrange is from chromosome 17, containing breast cancer genes, including BRCA1, which is associated with 40 percent of inherited breast cancer cases.

The researchers believe that if 30,000 players solve 50 games each, this “herd intelligence” would produce enough data to reveal the reference map of the 20,000 genes in this breast-cancer cell line.

Marti-Renom and his team sought to visualize the genome in three dimensions but realized this would need tremendous resources in terms of artificial intelligence (AI) and computational power. Instead, GENIGMA allows players to generate data to update reference maps in conjunction with AI.

After logging onto GENIGMA, players solve puzzles involving blocks of different shapes and colors to achieve the highest score. Each string of blocks represents a genetic sequence in a cancer cell line. When players organize the blocks, the developers hope, they may find a solution to the location of genes and their correct sequence on a reference map.

Edited by Siân Speakman and Kristen Butler

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How Majority of Jefferson County Commission Likely Just Got Re-Elected

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Jefferson County Commissioners, from left, Sheila Tyson, Jimmie Stephens, Joe Knight, Lashunda Scales and Steve Ammons. (Jefferson County Public Information Office)

By Barnett Wright

The Birmingham Times

Energy Efficient LED Light Towers Being Installed at Historic Legion Field

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Legion Field light tower on the ground —January 30, 2022. (Pat Byington/Bham Now)

By Pat Byington

bhanow.com

Cheslie Kryst, 30, Former Miss USA, One of Three Black Pageant Winners in Same Year

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FILE - Miss North Carolina Cheslie Kryst wins the 2019 Miss USA final competition in the Grand Theatre in the Grand Sierra Resort in Reno, Nev., on May 2, 2019. (Jason Bean/The Reno Gazette-Journal via AP, File)

 

Fishing For Compliments: ‘Talking’ Fish Chatter About Food And Sex

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A three-spot squirrel fish (Sargocentron cornutum) is a tropical species identified during a Cornell University study of sound communication among fish. (Jeffrey T. Williams)



By Martin M Barillas

Swimmers and divers should not be surprised to find that some fish may be “talking” underwater, according to a new study on fish sounds.


Researchers at Cornell University, who published their research in the journal Ichthyology & Herpetology, say that fish are more likely to use sound to communicate than previously thought. In fact, the scientists say some species have done so for 155 million years.

“We’ve known for a long time that some fish make sounds,” said lead author Aaron Rice of Cornell. “But fish sounds were always perceived as rare oddities. We wanted to know if these were one-offs or if there was a broader pattern for acoustic communication in fishes.”

The team looked at ray-finned fish — so called because their webbed fins are supported by bony spines, or rays — which comprise 99 percent of known fish species. They found 175 families of fish in the ray-finned family tree that together contain two-thirds of the fish species that are known to, or likely to, communicate with sound.

The authors found that sound evolved at least 33 separate times over the course of millions of years, an indication of its high importance.

Considered a trash fish by anglers in the Gulf of Mexico, the Gulf toadfish (Opsanus beta) was among the species identified by Cornell University researchers in a study on sound communication among fish. (Aaron Rice)

“Thanks to decades of basic research on the evolutionary relationships of fishes, we can now explore many questions about how different functions and behaviors evolved in the approximately 35,000 known species of fishes,” said study co-author William Bemis of Cornell. Having abandoned a “strictly human-centric way of thinking,” Bemis said, “what we learn could give us some insight on the drivers of sound communication and how it continues to evolve.”

The sources of information for the study include extant scientific papers and recordings of fish sounds, references in literature from before the advent of underwater recordings, and the anatomy of the fish, including whether they have the right sound-generating organs, such as an air bladder, sound-specific muscles and specific bones.

“Sound communication is often overlooked within fishes, yet they make up more than half of all living vertebrate species,” said co-author Andrew Bass, also of Cornell, noting that studies of underwater communication have focused on cetaceans, such as whales and dolphins. Bass said that fish have been overlooked “because [they] are not easily heard or seen… But fishes have voices too.”

Rice said fish communicate among themselves about more or less the same things humans do: sex and food. When fish seek a mate, communicate their location or defend a territory, they make themselves known. He said that many fish bear names alluding to the sounds they make, such as grunts, croakers, trumpeters, squeaking catfish and hog fish.

For his part, Rice will continue tracking new sounds discovered among fish and add them to his database. “This introduces sound communication to so many more groups than we ever thought,” said Rice. “Fish do everything. They breathe air, they fly, they eat anything and everything — at this point, nothing would surprise me about fishes and the sounds that they can make.”

Edited by Siân Speakman and Kristen Butler

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The post Fishing For Compliments: ‘Talking’ Fish Chatter About Food And Sex appeared first on Zenger News.

Don’t Blink: Mysterious Object In Space Surprises Scientists

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The Murchison Widefield Array radio telescope in Australia offered a new view of the Milky Way. Above, the lowest frequencies are in red, middle frequencies in green, and the highest frequencies in blue. The star icon shows the position of the mysterious object emitting intermittent signals. (Natasha Hurley-Walker/International Centre for Radio Astronomy Research/Curtin University/GLEAM)



By Martin M Barillas

While scanning the skies for cosmic radio signals, astronomers found a mysterious celestial object never observed before that releases bursts of energy three times per hour.


“This object was appearing and disappearing over a few hours during our observations,” said Natasha Hurley-Walker, an astrophysicist at Curtin University and the International Centre for Radio Astronomy Research in Australia. “That was completely unexpected. It was kind of spooky for an astronomer because there’s nothing known in the sky that does that.”

Hurley-Walker, who led a team that published a study about the discovery in the journal Nature, noted that “it’s really quite close to us — about 4,000 light-years away. It’s in our galactic backyard.”

The spinning object was discovered in 2021 by co-author Tyrone O’Doherty of Curtin University using a Murchison Widefield Array (MWA) telescope in Australia after observing the same section of the sky over a 24-hour period. It may be a so-called white dwarf star or neutron star or even many collapsed stars, all of which have an ultra-powerful magnetic field.

The Murchison Widefield Array radio telescope captures radio waves emitted from celestial bodies across the universe. (Natasha Hurley-Walker/International Centre for Radio Astronomy Research/Curtin University)

Hurley-Walker and her colleagues found that the newly detected object appears to be spinning much more slowly than other magnetars, which could indicate that it has outlived other magnetars that typically last only a few thousand years.

A magnetar is a type of dead star that has burned up its fuel and collapsed into a dense spinning object with a powerful magnetic field. They are typically found only in places where new stars have appeared.

The newly discovered object has been blasting a radiation beam for one minute out of every twenty, making it one of the brightest radio emitters in the sky.

Objects that emit radiation in phases are called “transients.” Co-author Gemma Anderson noted that “when studying transients, you’re watching the death of a massive star or the activity of the remnants it leaves behind.” She said the object being studied is smaller but brighter than our sun and emits highly-polarized radio waves, which means it may have an extremely strong magnetic field.

Supernovae, or exploding stars, like slow transients, become apparent over the course of a few days and then disappear after a few months. Pulsars, or neutron stars, and fast transients release beams intermittently within milliseconds or seconds. Anderson said that finding a celestial object that turns on for a minute is very unusual.

An artist’s impression of a magnetar. While magnetars are known to rotate every few seconds, theoretically, “ultralong period magnetars” could rotate much more slowly. (International Centre for Radio Astronomy Research)

For Hurley-Walker, her team’s observations may mean that they have discovered an ultra-long period magnetar. She described it as a “slowly spinning neutron star” that had only been considered in theory. “But nobody expected to directly detect one like this because we didn’t expect them to be so bright,” she said. The object is converting magnetic energy to radio waves much more effectively than anything previously known, she said.

Hurley-Walker continues to monitor the object with the MWA, hoping to observe it switching back on. “If it does, there are telescopes across the Southern Hemisphere and even in orbit that can point straight to it,” she said.

By reviewing the MWA archives, she hopes to find similar objects. “More detections will tell astronomers whether this was a rare one-off event or a vast new population we’d never noticed before,” she said.

Edited by Siân Speakman and Kristen Butler

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4 of 5 Jeffco Commissioners Face No Opposition in May 24 Primaries

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The Jefferson County Commission, from left: Joe Knight; President Pro Tem Lashunda Scales; President Jimmie Stephens; Sheila Tyson and Steve Ammons. (FILE)

By Barnett Wright

The Birmingham Times

Sam Shade Introduced as Miles College’s Head Football Coach

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Sam Shade was named Friday as head football coach at Miles College. (Solomon Crenshaw Jr., For The Birmingham Times)

By Solomon Crenshaw

For The Birmingham Times

Birmingham Police Chief Patrick Smith Resigns; Interim Named

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Patrick Smith, left; Scott Thurmond

The Birmingham Times