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SWAC Releases All Conference Football Teams

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SWACDray Joseph (Southern), Arnold Walker (Alcorn State), Jer-ryan Harris (Arkansas-Pine Bluff), Kourtney Berry (Alabama State) and Javancy Jones (Jackson State) lead the SWAC’s 2013 postseason accolades

BIRMINGHAM, Ala. – Southern University, Alcorn State University, Jackson State University and University of Arkansas at Pine Bluff received the four major 2013 Southwestern Athletic Conference postseason football awards in voting conducted by league head coaches and sports information directors. The conference made the announcement on Friday prior to the 2013 Toyota SWAC Football Championship on Saturday, Dec. 7, at Reliant Stadium in Houston.

Southern senior quarterback Dray Joseph and Alcorn State senior running back Arnold Walker were named Co-Offensive Player of the Year. Arkansas-Pine Bluff senior linebacker Jer-ryan Harris was tabbed Defensive Player of the Year while Alabama State’s redshirt freshman linebacker Kourtney Berry landed the Newcomer of the Year award. Rounding out the postseason accolades, Jackson State defensive lineman Javancy Jones was tagged Freshman of the Year.

Alcorn State and Alabama State led the way with 10 selections apiece with both landing five players on the first team. Jackson State was second with eight picks with four receiving first-team honors. The count includes Alabama A&M and Prairie View A&M with six apiece, Southern and Texas Southern each with three, and Mississippi Valley State posting both selections on the first team. Arkansas-Pine Bluff and Grambling State close out the list with a player on this year’s postseason squad.

Joseph led Southern to an 8-4 overall record (7-2 SWAC) and its first Western Division title since 2004. He helped SU post its first winning season since 2009 becoming the school’s all-time leader in passing yards on Nov. 16 vs. Clark Atlanta. Joseph finished out the season with a league best, 3,236 passing yards, becoming the second quarterback in school history to throw for more than 3,000 yards in a single season. He leads the SWAC in passing yards per game (269.7) and passing touchdowns (27). Joseph passed for over 200 or more yards in 10-of-12 games during the regular season.

Walker capped his collegiate career leading Alcorn State and the SWAC in rushing yards (1,191) and rushing touchdowns (16). He averaged 5.3 yards per carry and led the SWAC averaging 99.2 rushing yards per game. He finished second in the SWAC in scoring (96) and ranks fourth in the conference in all-purpose yards (1,368). Walker claimed Alcorn State’s 30-year old all-time career rushing record  with 2,806 yards. He also claimed the record for most points scored in a season. For the year, he rushed for at least 100 yards in 7-of-12 games recording 100 or more yards in six straight contests. He helped power Alcorn State to a 9-3 record (7-2 SWAC), the Braves’ first winning season since 2006 and nine-win campaign since 1984.

Harris anchored UAPB’s defense finishing atop the SWAC in tackles with 107 (56 solo). He currently sits sixth in the FCS. To close out the season, he gathered three tackles for loss (7 yards), one quarterback hurry, and a fumble recovery returned for a 37-yard touchdown.

In his first season on the field for JSU, Jones recorded 48 tackles (21 solo) to go along with a team high, 12 tackles for loss. He captured five sacks, two pass deflections, a forced fumble, blocked kick and a defensive touchdown (punt block recovery). Early in the year, he was nominated for the Jerry Rice Award. (FCS Freshman of the Year).

In his first collegiate season after responding from an injury that applied a redshirt year, Berry posted a team-leading 107 total tackles (57 solo, 48 assists) in the 11 games. In addition, he complemented his stops with seven sacks and 11.5 tackles for a loss. He also finished the year with an interception, two fumble recoveries, three pass break ups and two quarterback hurries. Berry was named the SWAC Defensive Player of the Week once, the league’s Newcomer of the Week twice, while spotlighting a defense that finished second in the SWAC in points allowed (25.8). He was also selected as a nominee for the Jerry Rice Award (FCS Freshman of the Year.

Joseph, Walker, Harris, Berry and Jones join the 2013 All-SWAC Football First Team that includes: running back Isaiah Crowell (Alabama State), offensive linemen – Issac Sampson (Alcorn State), Dillon Bonnet (Prairie View A&M), Edmond Davis (Alabama State), Jordan Arthur (Jackson State), Johnathan Smith (Jackson State), wide receivers – Deandre Cooper (Prairie View A&M), Lee Doss (Southern) tight end Johnathan Dorsey (Alabama A&M), place kicker Haiden McCraney (Alcorn State), punter Bobby Wenzig (Alabama State)  return specialist Tavoris Doss (Alcorn State), defensive lineman Derrick Billups (Alabama State), Amir Bloom (Texas Southern), Robert Simpson (Mississippi Valley State), linebacker Robert Nelson (Alabama A&M) and defensive backs Qua Cox (Jackson State), Avery Boykin (Mississippi Valley State), Brandon Thomas (Texas Southern) and C.J. Morgan (Alcorn State).

Co-Offensive Player of the Year

Dray Joseph (Southern)

Arnold Walker (Alcorn State)

Defensive Player of the Year


Jer-ryan Harris (Arkansas-Pine Bluff)

FIRST TEAM


Offense

QB -Dray Joseph (Southern)

RB – Isaiah Crowell (Alabama State)

RB – Arnold Walker (Alcorn State)

OL – Issac Sampson (Alcorn State)

OL – Dillon Bonnet (Prairie View A&M)

OL – Edmond Davis (Alabama State)

OL – Jordan Arthur (Jackson State)

OL – Johnathan Smith (Jackson State)

WR – DeAndre Cooper (Prairie View A&M)

WR – Lee Doss (Southern)

TE – Johnathan Dorsey (Alabama A&M)

Defense


DL – Derrick Billups – (Alabama State)

DL – Amir Bloom (Texas Southern)

DL – Javancy Jones (Jackson State)

DL – Robert Simpson (Mississippi Valley State)

LB – Jer-ryan Harris (Arkansas-Pine Bluff)

LB – Kourtney Berry (Alabama State)

LB – Robert Nelson (Alabama A&M)

DB – Qua Cox (Jackson State)

DB – Avery Boykin (Mississippi Valley State)

DB – Brandon Thomas (Texas Southern)

DB – C.J. Morgan (Alcorn State)

K – Haiden McCraney (Alcorn State)

P – Bobby Wenzig (Alabama State)

RS – Tavoris Doss (Alcorn State)

Newcomer of the Year


Kourtney Berry (Alabama State)

Freshman of the Year


Javancy Jones (Jackson State)

SECOND TEAM


Offense
QB – Jerry Lovelocke (Prairie View A&M)

RB – Barrington Scott (Alabama A&M)

RB – Courtney Brown (Prairie View A&M)

OL – Derrick Jead (Jackson State)

OL – Jonathan Scott (Alcorn State)

OL – Anthony Mosley (Southern)

OL – Robert Roquemore (Alabama State)

OL – Detonio Dade (Alcorn State)

WR – Zach Pendleton (Jackson State)

WR – Montarius Smith (Alabama A&M)

TE – Jordan Payne (Alcorn State)

Defense

DL – Deion Roberson (Alcorn State)

DL – Carlton Jones (Alabama State)

DL – Tedderick Terrell (Jackson State)

DL – Edward Mosley (Alabama State)

LB – Raheem Cardwell (Prairie View A&M)

LB – Jerome Howard (Prairie View A&M)

LB – Steve Orisakwe (Grambling State)

DB – Lawrence Barnett (Alabama A&M)

DB – Derrick Harris (Alabama A&M)

DB – Devon Francois (Alcorn State)

DB – Cameron Loeffler (Jackson State)

K – Bobby Wenzig (Alabama State)

P – Cory Carter (Texas Southern)

RS – Myles Everett (Alabama State)

The Southwestern Athletic Conference (SWAC), established in 1920, is a college athletic conference headquartered in Birmingham, Ala., which is comprised of historically Black universities in the Southern United States. It participates in the NCAA’s Division I for all sports and the Football Championship Subdivision (FCS).

Yana’s Christmas Prayer

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YANARefuge in (RITT) Troubled Times presents Yana’s Christmas Prayer with RITT
Monday, December 23 at The Harbert Center, 2109 4th Avenue, North, Birmingham, Ala., 6-9p.m.

Yana’s parents took her shopping. They asked what was her desire for Christmas.
Yana replied: I want nothing for myself; just give my gifts to the children who have no parents. Ashley, Yana’s mom, called RITT; her prayer began to become reality. Many of our children’s father or mother have lost their life by homicide or senseless violence. Some of these children are being supported by grandparents with little or no income enough to support a little one, let alone themselves. Will you help make “Yana’s Christmas Prayer with RITT” become true for them with so little. Drop off site is at the Dollar General on 3rd Avenue West by Burger King across from Shell Service Station. You may enter the store to make purchases also.

Donations are welcomed. We are a 501(c) (3) nonprofit organization. All gifts are tax-exempt.

Thank you in advance, Brenda Paige Ward, Founder
Contact: 205-240-9910 for ADS or Pick-up.

Panache PreHoliday Luncheon

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from left: Susan Rains,Jothany James, Carole Rose,Carmelita Bivens, Connie Patton, Michelle Machazire, Rosemary Ashford.
from left: Susan Rains,Jothany James, Carole Rose,Carmelita Bivens, Connie Patton, Michelle Machazire, Rosemary Ashford.
from left: Susan Rains,Jothany James, Carole Rose,Carmelita Bivens, Connie Patton, Michelle Machazire, Rosemary Ashford.

The lovely ladies of Panache had a preholiday  luncheon at Chuy’s to kick off the holiday season. Delicious food and great fellowship was enjoyed by all.

Nalls Brothers at the Iron Bowl

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Reginald Nall, James Owens, and Ronald Nall
Reginald Nall, James Owens, and Ronald Nall
Reginald Nall, James Owens, and Ronald Nall

Reginald and Ronald Nall spent their first and quite exciting Iron Bowl at Jordan-Hare Stadium with Reverend James Owen and his wife Gloria. He is the first Black Football scholarship player at the University of  Auburn in 1969. His nephew, Ladarius Owens is linebacker for SEC
Western Division Champions Auburn Tiger. The Nall brothers were teammates at Fairfield High School.

TWENTY YEARS OF FRIENDSHIP AND SERVICE

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On Saturday, November 2, 2013, members of Magic City (AL) Chapter of The Links, Incorporated, gathered for a luncheon to celebrate 20 years of “friendship and service” to the Birmingham-Jefferson County community. The event was held at The Club, where the Magic City Chapter was chartered in 1993 by then National President Marion Schultz Sutherland, Chapter Establishment Officer Marion Ridley Sweeney and Southern Area Director Katie Bell.
A Friendship Ceremony led by chapter president, Charletta T. Sheehy set a celebratory tone for the event, which was chaired by Connie Sheppard Harris. Deidra Perry served as Mistress of Ceremonies, and members Connie S. Harris, Deborah B. Walker, and Margaret Z. Beard participated in the program as well. A photo presentation by Donna Lawson brought memories and laughter to the crowd.
Charter members in attendance included: Adriene Balton-Topping, Margaret Z. Beard, Diana T. Chambliss, Connie Sheppard Harris, Bettye Warren Mitchell, Charletta T. Sheehy, Sharon Spencer, M.D., Juanita Jordan Vann, Deborah Byrd Walker and Michelle Williams-Bridgewater.
Joining in the celebration were members inducted  from 2000 – 2012: Stacy Haynes-Nelson, M.D., Sandra Z. Harris, Gloria Jemison, Nichelle Gainey, Joyce P. French, Cheri Gardner, Terri Gardner, Merika Coleman-Evans, Adrienne Royster-Bell, Mary B. Williams, Melissa Howard Smoot, KeAndrea Stephens Jones, Donna R. Lawson, Lila E. Hackett, Belinda J. Hall, Karen Winston Fox, Barbara Regan, Marguerite Johnson, Nena Moorer, Cecilia Crenshaw, LaJuana Bradford, Deidra K. Perry and Brandi Rudolph Bolling, M.D.
Alumni members honored for their service to the chapter included Willa R. McGlothan, Margaree Martin, Juanita J. Balton and Sara Myers.
Guests included Connecting Links Leonard Smoot, Cleophas Vann, Frederick Bolling, Clifford Hall and Reverend James Myers. Also Ms. Diane Rudolph.
The Links, Incorporated founded in 1946 is one of the oldest and largest volunteer service organizations for women who are committed to enriching and ensuring the culture and economic survival of African American and persons of African ancestry. The Links, Incorporated has membership of over 12,000 professional women of color serving 272 chapters in 42 states, the District of Columbia and the Commonwealth of the Bahamas.
Through its philanthropic arm, The Links Foundation, Incorporated, the organization has contributed more than 24 million dollars to charitable causes since its founding.  Links have contributed 1.2 million documented hours of volunteer service during the 2006-2008 biennium, to assist communities throughout the United States and developing countries in Africa.

Local Students Get a History Lesson in Their Backyard

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The Birmingham (AL) Chapter of the Links, Incorporated to Host Civil Rights Program at Parker High School

BIRMINGHAM, Ala. –  A select number of Parker High School juniors and seniors participated in a one-day symposium at A.H. Parker High School on Wednesday, November 6, from 9a.m. until 12:30p.m. to commemorate the 50th anniversary of the civil rights movement.
The event, “History in Your Backyard,” highlighted Birmingham foot soldiers who helped fight for justice and equality in the 1960s. Speakers included Circuit Judge Helen Shores Lee and Barbara Shores, daughters of famed Birmingham civil rights attorney Arthur Shores. Each student received a signed copy of The Gentle Giant of Dynamite Hill , which is about Arthur Shores’ life written by his daughters.
The goal of the program was to provide students with a better understanding of Birmingham’s civil rights movement and the significant roles that people in the students’ very own community played to make the movement of 1963 a movement that changed the world. Students learned about the critical role Parker High School students played in the movement, heard the Shores’ sisters’ accounts of growing up with their father and viewed photos from the movement. “The Barber of Birmingham,” an Academy Award-nominated documentary about the life of Birmingham foot soldier and barber James Armstrong, was also shown.
Parker High School History:
A. H. Parker High School was conceptualized as the first public high school for Black students in Birmingham. In 1900, its initial enrollment consisted of 18 students. Today, it serves 871 students in grades 9-12.  Daryl Hudson is the principal.
Notable former students and alumni include:
•    Carole Robertson, one of the four girls killed in the bombing of the Sixteenth Street Baptist Church on September 15, 2013
•    Oscar Adams, Jr., Alabama Supreme Court Justice
•    Anne Marie Adams, Jefferson County Court Clerk
•    Herman “Sonny” Blount, jazz musician, known as “Sun Ra”
•    Erskine Hawkins, musician
•    Lola Hendricks, African-American civil rights activist
•    John Rhoden, sculptor and head of the Art Commission of the City of New York
•    Katherine Burt’s Brooke, Freedom Rider

The Links, Incorporated is an international, not-for-profit corporation, established in 1946. The membership consists of 12,000 professional women of color in 276 chapters located in 41 states, the District of Columbia and the Commonwealth of the Bahamas. It is one of the nation’s oldest and largest volunteer service organizations of extraordinary women who are committed to enriching, sustaining and ensuring the culture and economic survival of African Americans and other persons of African ancestry. Links members contribute more than 500,000 documented hours of community service annually – strengthening their communities and enhancing the nation. The organization is the recipient of awards from the UN Association of New York and the Leon H. Sullivan Foundation for its premier programs.

The Birmingham Chapter, Alabama’s first chapter, began with a core group called “Pacesetters”, consisting of eight women: Hattie Calloway, Columbia Clayborne, Madeline Davis, Mayo Forniss, Minnie Gardner Gaston, Theodora Shores, Bernice Sterling and Essie Taggart. Area Director Georgia Schank installed the charter members on February 4, 1956.
The Birmingham Chapter continues to be a leading organization in the community in the areas of service and philanthropy. The support of the community and dedication of resourceful Link members have resulted in programs, scholarships, and activities that have benefited the Birmingham community.

Local barber opens shop in Bluff Park

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Local Barber_3Local Barber_1Local Barber_2  By Jessica Jones

Angelica Littleton is the new barber on the block as she opens her new barbershop, Artistic Designs, in Bluff Park. A newcomer to the area, she’s no novice when it comes to cutting hair. Littleton has been cutting hair for 16 years and has been a professional barber since she graduated from Lawson State in 2006. Her interest in barbering began when she first picked up a pair of clippers to help line up her boyfriend she had at the time, or so she thought.
She later found out that she came from a family of hair stylists. “Before my grandmother passed this year she told me her father was a barber and he had his own barbershop,” Littleton said. Her great grandfather owned Jones Barber and Beauty Salon in Avondale. Littleton’s great grandmother was also a stylist. Her great grandfather’s uncle and his nephews were barbers as well.
Throughout her high school years, cutting hair was a good source of pocket change, but Littleton hasn’t always wanted to be a barber.
“I would cut hair on the porch or as a side thing, but I never expected that to be my career. Never,” she said. Unsure of what she wanted to do after high school, Littleton didn’t attend school for barbering until 2004. “Didn’t know God had this thing set up for me to be a barber.”
After working at other shops, she’s now the owner of Artistic Designs Lounge in Bluff Park, a diverse location perfect for Littleton who cuts all types of hair. But she didn’t do it alone. Lawrence Carpenter, owner of U R Next barbershop and a high school friend, had been after her for years to own her own shop, but she never felt she was ready.
“He wanted me to run his shop in West End,” she said. “He heard the buzz about me and I didn’t know it. Everybody was talking about that female barber…and I didn’t know that. He said ‘Angel, I need you to come run my shop,’ and I said, ‘I can’t do that. The Lord hadn’t led me [there].’”
Concerned about the loyalty of her clients who lived in the Homewood and Hoover area, she didn’t want her clients to have to relocate. For five years he asked her to help him run his shop and for five years she declined.
“What the Lord said to me is I had a fear of succeeding and tried to call it a fear of failure,” Littleton said.
She quit her job at the shop she worked in at the time and went in search for a building for her new business. After searching with no success, she called Lawrence who told her at that moment, he was at the building that was to be her new shop and had been waiting for her to call him. Finally, she said yes and moved into her shop a little over six weeks ago. It’s a leap Littleton said she’s glad she made.
“The peace that God has given me owning my own shop, it has been wonderful,” she said.
Along with her career choice came the stereotypes that barbers, both male and female, face about the legitimacy of a craft that is often seen as a hustle. There is a belief that barbers don’t go to school or don’t have a real career, she explained.
“That’s a lie,” she said. “When I attended Lawson in 2004, I had to take psychology. I had to take math. I had to take the Science of Barbering, the History of Barbering. I didn’t just cut hair.” She completed two years of school before she earned her license. “You go to school for this. This is not a hustle.” “I’m able to educate my clients on the hair part and the science part and also the history part of [barbering] because I went to school for it.”
As if being stereotyped as uneducated isn’t enough, there is also the issue of gender. In a male dominated field, Littleton has often had to prove herself as being just as good as male barbers. She’s had plenty of encounters with men who were reluctant to allow a woman to cut their hair, but one moment in particular stands out in her mind as the most memorable. Known as “the female barber who cuts fast but precise,” she’d just finished cutting four clients when a new client walked through the door. When she signaled for the next client to come over, he refused.
“He said ‘uh,uh I’m not going to let you cut my hair,’” she said. She attributed his refusal to her attire that she describes as being feminine. “Most female barbers are hard and that’s what they (male clients) are looking for if they can cut hair.”
It wasn’t until after another client walked in and sat in her chair to get his hair cut that he allowed her to cut his hair once he saw the other barbers weren’t as fast as Littleton. She earned a new faithful client that day,
Despite the stereotypes and misconceptions of being a barber, owning her own shop also comes with rewards, she said.
“Being the shop owner, I’m able to set my own atmosphere,” she said. “If I’m peaceful, then the atmosphere will be peaceful. There’s a stability in the atmosphere so that’s one of the biggest things [I enjoy].”
That stable atmosphere is one of the things that keeps client Cliff Long coming back.
“I like the atmosphere,” Long said. “It’s a family friendly atmosphere. I can bring my daughter here and I don’t have to worry about barbershop talk and barbershop talk literally runs the gamut.”
“I like the professionalism,” he said. “I like the fact that if I call she can let me know if she can fit me in her schedule. I have a very busy work schedule. I don’t have a lot of time, so for me, when I do need a haircut, it’s on a schedule and I need someone who’s professional. Barbers are notorious for having you sitting in the shop all day long and I never have experienced that with Angel.”
Artistic Designs Lounge is located at 2400 Mountain Drive Suite 104, 35226.

Deltas Sponsor Christmas on Meadow Lane

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“A Celebration of Family Literacy” was the theme of Christmas on Meadow Lane, an Open House event, sponsored by DELTA Incorporated (Developmental Enhancement Life and Training Alliance) and the Birmingham Alumnae Chapter, Delta Sigma Theta Sorority, Incorporated. Held Sunday, December 1 from 4-6 p.m., the program featured outstanding Christmas music performed by the Children and Intermediate choirs of Sixth Avenue Baptist Church, under the direction of Janice Wilson, who was accompanied by Evie Morris. Such time loved songs as “Happy Birthday, Jesus,” “Jesus Is the Reason For the Season,” “Because of Who You Are,” and “Joy To the World,” delighted the jubilant audience. Delta Choraliers, the sorority’s choir, also pleased the audience with their rendition of “Carol of the Bells.” Other crowd pleasers were Carmen Cantelow and Rodney Davis who sang, “The Prayer,” and Christian Blevins, who sang the all-time favorite, “O Holy Night.”
Guest and sorority members were welcomed to the event by Shirley Witt Taylor, President of Birmingham Alumnae Chapter and the occasion was given by Mary Hughes, DELTA Incorporated Board Chair. The audience joined in a responsive reading of a holiday litany, “We Celebrate the Baby,” led by Bonita Chaney.
Another highlight of the afternoon was the official lighting of the beautiful Delta Christmas Tree, an inspiring activity which focused on the tree lights as symbols of Jesus being the Everlasting Tree of Life. The lighting ceremony was led by Brenda Rudolph, Vice-Chair of DELTA Incorporated and Felecia Dailey, Vice-President of Birmingham Alumnae Chapter. An appropriate program ending to the Celebration of Family Literacy was the reading by Gloria Dennard of the classic Christmas book, The Polar Express.  Gloria Dennard also served as the mistress of ceremony for the program.
Closing remarks were made by Brenda Rudolph, chair and Olinda Cook, co-chair of Christmas on Meadow Lane. Open House activities which followed, consisted of a delicious array of delectable refreshments, free books for children, visits with Santa Claus, (Lloyd Culpepper) and shopping opportunities with the various vendors on hand.
Christmas on Meadow Lane was supported by the Educational Development Committee, EMBODI, artist, LeDarrius Horn, Delta Academy, Delta GEMS, The Literacy Council of Central Alabama, and Walt Worthem. Books were also donated by Birmingham Alumnae Chapter members.

DELTA Incorporated (Developmental Enhancement Life and Training Alliance) is the 501 (c) (3) entity of Birmingham Alumnae Chapter. Established on May 14, 1993, this philanthropic corporation is a nonprofit entity that operates exclusively for charitable and educational purposes, and is empowered to enhance and expand the support of programs and activities of Birmingham Alumnae Chapter. Members of the Board of Directors are Mary Hughes, Brenda Rudolph, Cynthia Daniels, Gwen Childress, Cynthia Abernathy, Valerie Cottingham, Shirley Taylor, Alexis Fitzpatrick, Gubray Brooks, Bonita Chaney, Doris Maddox, Muriel Weatherly, Olinda Cook, and Candice Reese.

HIV-1 accessory protein helps induce metabolic defects

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HIVHOUSTON – The wily human immunodeficiency virus (HIV-1) has another trick up its sleeve, one that can disrupt cellular metabolism and raise the risk of heart disease, diabetes and osteoporosis in patients already receiving treatment to fight HIV, said researchers led by those at Baylor College of Medicine (www.bcm.edu) in a report that appears online in the journal Science Translational Medicine (http://stm.sciencemag.org/).
The culprit is an HIV-1 accessory protein known as viral protein R (Vpr). The findings reported by the researchers answer some of the questions as to why patients receiving successful treatment for HIV end up with abnormal fat loss and deposits – a problem call lipodystrophy.
“With antiretroviral treatment, HIV has become a chronic illness, and lipodystrophy and associated metabolic defects have become, long-term, serious complications,” said Dr. Ashok Balasubramanyam, professor of medicine – diabetes, endocrinology and metabolism at BCM. “It appears that latent or hidden HIV is dangerous not only because it can flare up if treatment is interrupted, but also because it keeps producing toxic signals that make HIV disease (despite the best antiviral treatment) a chronic, metabolically debilitating illness with high risk of diabetes, cardiovascular disease and obesity. This adds to the urgent need for a real cure for HIV, i.e., ways of wiping out all traces of HIV even in reservoirs where it currently hides out.”
Because the HIV lipodystrophy syndrome was first noticed around the time that the successes of anti-retroviral drugs became apparent, most clinicians assumed that the drugs were the cause. However, research shows that while the drugs may play a role, some of the problems with lipids in the blood and glucose levels and diseases associated with those problems continue, even if the drugs are changed or newer drugs are used. Fat metabolic defects also exist in patients who are untreated or have a genetic quirk that prevents the virus from destroying their immune systems after infection.
In this case, Balasubramanyam and his colleagues focused on HIV-1 virus protein R (Vpr), which can co-activate the glucocorticoid receptor and co-repress proliferator-activated receptor gamma (PPARgamma), both factors that play key roles in cellular metabolism.
“We found that Vpr circulates in the blood of patients with no detectable viral load after treatment with the best antiviral drugs,” said Balasubramanyam. “This implies that ‘latent’ or ‘persistent’ HIV that is hiding out in reservoirs is constantly turning out Vpr, which can cause the metabolic defects.”
“It appears to work as a toxic hormone that is sent out from infected cells to attack others than cannot be infected directly by HIV-1,” he said. This protein can easily infiltrate fat and liver cells, where it disrupts some of the genetic machinery and regulating proteins crucial to metabolic function.
“These metabolic pathways get disrupted, resulting in excessive breakdown of fat stores, increased release of fats into the bloodstream, and insulin resistance,” he said.
In studies in mice, he and his colleagues, including first authors Dr. Neeti Agarwal, a post-doctoral associate, and Dr. Dinakar Iyer, an instructor in the department of medicine – diabetes, endocrinology and metabolism, both at BCM, found that mice that produce Vpr in the liver and fat cells suffer disruption of metabolic pathways. In another experiment, they pumped Vpr in mice as though it were a drug to recreate what happens in patients. Again, the metabolic pathways were disturbed.
“One big surprise was how closely the specific defects in each model resembled the defects in the other – proof that not only is Vpr capable of disrupting these metabolic pathways, but can do so when introduced into the bloodstream of the mice. The second was the finding of fatty liver in these mice. Fatty liver is very prevalent in HIV patients, but we weren’t expecting it in these mice,” said Balasubramanyam. They found that Vpr interferes with pathways involving proper handling of fat by the liver.
Addressing the mechanisms mediated by Vpr might help HIV patients with the complications of insulin resistance, fatty liver, diabetes and heart disease, he said. One possibility might be using a drug or neutralizing antibodies to block the overall effect of Vpr. It might also be possible to use a drug such as mifepristone to block the glucocorticoid receptor, which Vpr activates.
“These findings add to the urgent need for a real cure for HIV, wiping out all traces of the virus, even in reservoirs where it hides,” he said.
It also suggests areas for further research with viruses, particularly those that are chronic or hide in the body for long periods, such as herpes, adenovirus or cytomegalovirus (CMV).
“It would be a good idea to focus research efforts on uncovering more connections between chronic infections and metabolic diseases. Hitherto infectious diseases and metabolic diseases have been considered to be separate and unconnected – I think it’s time to revise our thinking about that,” he said.
Others who took part in this research include: Rajagopal V. Sekhar, Toni Oplt, Eric D. Buras, Susan L. Samson, Maria C. Rodriguez-Barradas and Farook Jahoor, all of BCM; Terry M. Phillips and Tomoshige Kino, both of the National Institutes of Health; Ulrich Schubert of the University of Erlangen in Germany; Jacob Couturier and Dorothy.E. Lewis, both of the University of Texas Health Science Center at Houston; Jeffrey B. Kopp of the National Institute of Diabetes and Digestive and Kidney Diseases; and Sanjeet G. Patel of the University of California Los Angeles Medical Center in California. Balasubramanyam, Sekhar and Samson are also with Harris Health System’s Ben Taub  Hospital. Rodriguez-Barradas is also with the Michael E. DeBakey Veterans Affairs Medical Center. Buras is now with the University of Michigan in Ann Arbor.
This work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (Grant DK081553) and a Developmental Grant from the Baylor Center for AIDS Research (National Institute of Allergy and Infectious Diseases [Grant P30AI36211]), a Seed award (NIDDK Grant P30DK079638 [Diabetes Research Center at Baylor]), German Research Council (Grants SFB 796 and 643), the NIDDK Intramural Research Program, and the NIH Office of the Director.

Dr. Monique Hill-The Art of Dentistry

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Dr. Monique HillBy Charlene Holmes

Some say the eyes have it, but according to Dr. Monique Hill, “One of the first things that people notice is your teeth and your smile.”
Dr. Hill is a general dentist who has been in practice for seven years.
“I do a little bit of everything,” she said.
The  Detroit, Michigan native who relocated to Birmingham, Alabama while she was in high school, explained, “I became interested in dentistry when I was 12 years old. I had really crowded teeth and my dentist straightened them out with braces. I thought it was the coolest thing ever.”
She continued, “I enjoyed all of my art classes in high school and I wanted a profession that would allow me to tap into my artistic side.”
Dr. Hill said what she likes most about her job is “restoring people’s confidence and helping people that are in pain.”
She said with conviction, “There is not anything else that I think I would enjoy as much as being a dentist.”
In her spare time, Dr. Hill said, “I like to read, spend time with my dog, and occasionally indulge in some retail therapy.”
Dr. Monique Hill’s office is located in Hoover, Alabama on Highway 150.